Theoretical Immunology
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The immune system protects us from potentially infectious agents and our own malignant cells. It is made up of a variety of organs, cells, and molecules distributed throughout the body. Cell-cell, cell- molecule and molecule-molecule interactions are crucial for the functioning of the immune response, resulting in a highly complex dynamical system. The task of theoretical immunology is to unveil principles and mechanisms by which the immune system works, and why it can sometimes be defeated, using mathematical modeling and data analysis as its main tools. The lecture series will start with an introduction to the cells and molecules in the immune system and its basic biological features, leading then into the most up-to-date examples of the theory of modeling immunological problems.
Program
| Monday, October 14: | |
|---|---|
| 9.00 | Opening of the Autumn School |
| 9.15 - 10.45 | Alan Perelson, Los Alamos National Laboratory "Introduction to immune system modeling" |
| 11.15 - 12.45 | Rob de Boer, University of Utrecht "Diversity in the immune system" |
| 15.15 - 16.45 | Lee Segel, The Weizmann Institute of Science "Reverse engineering: A model for T-cell vaccination against autoimmune disease" |
| 18.15 | Public Lecture Alan Perelson, Los Alamos National Laboratory "Modeling HIV infection and treatment: Where are we and where are we going?" |
| Tuesday, October 15: | |
| 9.15 - 10.45 | Lee Segel, The Weizmann Institute of Science "Distributed feedback to enhance the immune system's performance of its overlapping and conflicting goals" |
| 11.15 - 12.45 | Alan Perelson, Los Alamos National Laboratory "Modeling HIV infection and treatment" |
| 15.45 - 17:15 | Rob de Boer, University of Utrecht, Netherlands "Large differences in the HIV viral load explained by small parameter differences" |
| 18:00 | Reception and Buffet Dinner |
| Wednesday, October 16: | |
| 9.15 - 10.45 | Lee Segel, The Weizmann Institute of Science "Th1 vs. Th2: (a) a model for allergy immunotherapy and (b) an example of how the immune system can provide appropriate responses to its challenges" |
| 11.15 - 12.45 | Rob de Boer, University of Utrecht, Netherlands "Mathematical models to interpret labeling data" |
Location:
| Room: | Lecture Hall 201 |
| Building: | Natural History Museum |
| Street: | Invalidenstraße 43 |
| ZIP Code: | 10015 |
| City: | Berlin |
Registration
For registration, send an e-mail with your name and address or a letter to Dr. Michal Or-Guil, Institute for Theoretical Biology, Humboldt-Universität zu Berlin, Invalidenstraße 43, 10115 Berlin, Tel.: 030-2093-9105, Fax: 030-2093-8801 before October 1. The registration fee of 25 Euro (to be paid upon arrival) includes the buffet on October 15. The registration fee for students is 13 Euro.
Publications
J.H.L. Playfair and B.M.Chain: Immunology at a Glance. Blackwell Science C. A. Janeway, P. Travers, M Walport and M. Shlomchik: Immunobiology Irun Cohen: Tending Adam's Garden: Evolving the Cognitive Immune Self. Martin A. Nowak and Robert M. May: Virus Dynamics: Mathematical Principles of Immunology and Virology. A. S. Perelson and G. Weisbuch: Immunology for Physicists. Reviews of Modern Physics 69,1219 (1997).