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Contact
Current MIT Department of Biology 77 Massachusetts Ave., 68-217 Cambridge, MA 02139 Tel: (617) 258 5995 Fax: (617) 253 3128 www Former Institute for Biology Department of Theoretical Biophysics Humboldt University Berlin Invalidenstr. 42 D 10115 Berlin, Germany Gene Expression Expression data Publications by topic Human Genome Data EnsEMBL Human Genome Central UCSC Downloads |
Dirk Holste, Humboldt University BerlinComputational Biology
I completed my PhD studies in Biophysics (2002) at the Humboldt University at Berlin. I have previously received two degrees in Nonlinear Dynamics Science (MSc, 1995) from University College London and in the fields of Physics (Diploma, 1997) from Humboldt-University at Berlin. My research interests lie in Computational Molecular Biology, an area perhaps covered by Theoretical Biology and Theoretical Physics, Statistics, Information Theory, or Scientific Programming. I worked for a year at the Institute for Theoretical Biology, after which I decided to start working towards a degree in the fields of Computational Molecular Biology. At that time I was working on a problem in statistical pattern recognition, namely the distiction between exon-intron from raw DNA sequence data. Sure enough, this has been right up my street ever since. What's more, I learned a lot about molecular biology, and it has become so severe that I changed from physics towards biology. Though, a lot of model building is going to enter my new fields of research, too. More recently, then, I find the highly parallel data accquisition on DNA microarrays and analysis of gene expression data aimed at revealing cellular strategies exciting. I try to come up with methods coping with these aquired data sets. My PhD work is carried out at the Theoretical Biophysics Group. In this field, I conduct studies concerning the following topics: structural composition and organization of DNA sequences, expressed regions (coding DNA/ORFs) and intra- and intergenetic regions, pre-processing, modelling, and classification of gene expression profiles.
In Fall 2000, I became Graduate Fellow at the Institute for Pure and Applied Mathematics, IPAM, where I experienced a three-months period filled with lectures, discussions, work, seminars, workshops, and conferences centered around Functional Genomics, or more to the point gene expression analysis. I exploit this stay to met up with other like-minded people, and also to explore Los Angeles and the countryside of California. With end of July, I joined the Computational Biology Lab headed by Christopher Burge, at MIT Department of Biology to pursue postdoctoral research.
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Recent Publications
Accepted and submitted papers, preprints, thesis, preparations, and poster Manuscript Manuscript prepared for ICCS Procedings 1998 InterJournal [267] Logistic Map Simulator Alpha version of a logistic map simulator (LOMAS) Molecular Bioinformatics Course and selected coursework in computational biology/molecular bioinformatics, original version Chris Burge Lab Computational biology @ MIT |
| ©Dirk Holste Last modified: Tue Jul 16 16:45:10 CEST 2002 | following W3C HTML 4.0 |
All theorems are true (1).
All models are wrong (2).
And all data are inaccurate.
What are we to do?
We must be sure to remain uncertain.
Lennard A. Smith
(1) Regrettably, their premises are never fulfilled in reality.
(2) Unless they are "perfect", in which case they are theorems (1).