computational Biology
Contact

Current
MIT
Department of Biology
77 Massachusetts Ave., 68-217
Cambridge, MA 02139

Tel: (617) 258 5995
Fax: (617) 253 3128
www


Former
Institute for Biology
Department of Theoretical Biophysics
Humboldt University Berlin
Invalidenstr. 42
D 10115 Berlin, Germany


Gene Expression
Expression data
Publications by topic


Human Genome Data
EnsEMBL Human Genome Central
UCSC Downloads


Dirk Holste, Humboldt University Berlin

Computational Biology

UCL Logo

I completed my PhD studies in Biophysics (2002) at the Humboldt University at Berlin. I have previously received two degrees in Nonlinear Dynamics Science (MSc, 1995) from University College London and in the fields of Physics (Diploma, 1997) from Humboldt-University at Berlin.

My research interests lie in Computational Molecular Biology, an area perhaps covered by Theoretical Biology and Theoretical Physics, Statistics, Information Theory, or Scientific Programming.

LOGO [ITB]

I worked for a year at the Institute for Theoretical Biology, after which I decided to start working towards a degree in the fields of Computational Molecular Biology. At that time I was working on a problem in statistical pattern recognition, namely the distiction between exon-intron from raw DNA sequence data. Sure enough, this has been right up my street ever since. What's more, I learned a lot about molecular biology, and it has become so severe that I changed from physics towards biology. Though, a lot of model building is going to enter my new fields of research, too.

LOGO [TBP]

More recently, then, I find the highly parallel data accquisition on DNA microarrays and analysis of gene expression data aimed at revealing cellular strategies exciting. I try to come up with methods coping with these aquired data sets. My PhD work is carried out at the Theoretical Biophysics Group. In this field, I conduct studies concerning the following topics: structural composition and organization of DNA sequences, expressed regions (coding DNA/ORFs) and intra- and intergenetic regions, pre-processing, modelling, and classification of gene expression profiles.

LOGO [ITB]

In Fall 2000, I became Graduate Fellow at the Institute for Pure and Applied Mathematics, IPAM, where I experienced a three-months period filled with lectures, discussions, work, seminars, workshops, and conferences centered around Functional Genomics, or more to the point gene expression analysis. I exploit this stay to met up with other like-minded people, and also to explore Los Angeles and the countryside of California.

LOGO [MIT]

With end of July, I joined the Computational Biology Lab headed by Christopher Burge, at MIT Department of Biology to pursue postdoctoral research.

GK
Dynamics
Evolution
Apart from these sites, I administered until end of July 2002 the websites of the Graduate Programme (DFG-GK 268) "Dynamics and Evolution of Cellular and Macromolecular Processes", created a new design for the GK World-wide web representation, and came up with the logo of the Graduate Programme.

Recent Publications
Accepted and submitted papers, preprints, thesis, preparations, and poster

Manuscript
Manuscript prepared for ICCS Procedings 1998
InterJournal [267]

Logistic Map Simulator
Alpha version of a logistic map simulator (LOMAS)

Molecular Bioinformatics
Course and selected coursework in computational biology/molecular bioinformatics, original version

Chris Burge Lab
Computational biology @ MIT
©Dirk Holste  Last modified: Tue Jul 16 16:45:10 CEST 2002 following W3C HTML 4.0

All theorems are true (1). All models are wrong (2). And all data are inaccurate. What are we to do?
We must be sure to remain uncertain. Lennard A. Smith
(1) Regrettably, their premises are never fulfilled in reality.
(2) Unless they are "perfect", in which case they are theorems (1).