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| - | ==== The Mammalian Circadian Clock ==== | ||
| - | All cells hold an internal clock able to generate daily rhythms. These endogenous rhythms are detected in 10% of all genes [1] and provide a way to react to external clues, to anticipate behaviour and to adapt molecular processes to specific day-times . Malfunctions of the circadian clock have been reported in the context of many diseases and disorders. Cancer is one such disease, although the mechanisms involved are not yet clear. Clock-controlled genes (CCGs) are involved in many molecular processes essential for malignant transformation of tumour cells [2]. The coupling of the circadian system to tumour progression is still an unexploited field of research. We use a systems biology approach involving wet-lab experiments, | ||
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| - | With such a methodology we aim to answer the following questions: | ||
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| - | How are the pathways, which connect the circadian clock to cancer, regulated? | ||
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| - | Is this regulation specific for different stages of tumour progression? | ||
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| - | Can a circadian signature for tumour progression be defined? | ||
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| - | With our research, we expect to be able to provide valuable insights into the mechanism of circadian regulation of tumourigenesis per se and to contribute to a better understanding of the cancer-clock system. As a perspective, | ||
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| - | 1. T. Bollinger, U. Schibler, Swiss Med Wkly. (2014) | ||
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| - | 2. S. Sahar, P. Sassone-Corsi, | ||
| - | 19935677]] | ||
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| - | 3. A. Relógio, //et al//., PLoS Genet (2014) [[http:// | ||