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groups:koenig:start [2017/03/02 11:33] – email updated koeniggroups:koenig:start [2022/03/25 12:33] (current) – koenig
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-====== Junior Group Systems Biology of Liver ======+
  
-{{:groups:koenig:koenig_bereich_03.png?500 }} Junior Group Leader\\ +====== Systems Medicine of Liver ====== 
- [[https://www.livermetabolism.com/contact.html|Dr. Matthias König]]+ 
 + 
 +{{:groups:koenig:koenig_500.png?200 }} **[[https://www.livermetabolism.com|Homepage]]**\\ 
 + 
 +**Group Leader**\\ 
 +[[https://www.livermetabolism.com/cv/|Dr. Matthias König]]\\
  
-Institute for Theoretical Biology\\ 
 Humboldt-University Berlin\\ Humboldt-University Berlin\\
-Invalidenstraße 43, 10117 Berlin, Germany\\ +Institute for Biology, Institute for Theoretical Biology\\ 
-phone +49 30 2093-8450\\ +Philippstraße 13, 10115 Berlin, Germany\\ 
-[[koenigmx@hu-berlin.de]] +phone +49 30 2093 98435\\ 
-\\ +**[[koenigmx@hu-berlin.de]]**\\
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-We are investigating liver metabolism and function with the help of computational models and methods.\\ +
-Read more about the group: [[https://www.livermetabolism.com|www.livermetabolism.com]]\\ +
-[[https://www.livermetabolism.com/|Projects]]\\ +
-[[https://www.livermetabolism.com/publications.html|Publications]]\\ +
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-The liver is the central metabolic organ of our body playing a crucial role in the clearance of +
-drugs, xenobiotics and numerous metabolites from the bloodstream. The quantification of these +
-liver functions is essential to assess the status of the liver, obtain information about the degree +
-of impairment, to evaluate treatment response or to select transplant recipients.+
  
-This project will establish a standardized multiscale model framework of the human liver readily 
-adaptable to various quantitative liver function tests currently used in the clinics. The resulting 
-models will be personalized with individual imaging data from CT and PET in combination with 
-anthropomorphic information like gender, age, body weight and height and used for the 
-evaluation of quantitative liver function tests in a personalized context. Within this project three 
-main applications will be realized, respectively represented by a showcase 
-  - normal liver function (galactose) 
-  - detoxification of drugs (drug cocktail, indocyanine green, bromsulphalein) 
-  - impaired liver (cirrhosis & liver disease) 
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-{{:groups:koenig:multiscale-galactose.png?nolink |}} 
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-| {{:groups:koenig:bmbf.png?nolink |}} | MK is supported by the Federal Ministry of Education and Research (BMBF, Germany) within the research network Systems Medicine of the Liver (LiSyM) (grant number 031L0054). | 
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